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Enzymatic synthesis of peptide in acetonitrile/supercritical carbon dioxide

✍ Scribed by Hidetaka Noritomi; Motokazu Miyata; Satoru Kato; Kunio Nagahama

Book ID
104656605
Publisher
Springer Netherlands
Year
1995
Tongue
English
Weight
258 KB
Volume
17
Category
Article
ISSN
0141-5492

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✦ Synopsis

The peptide synthesis from N-acetyl-L-tyrosine ethyl ester (Ac-Tyr-OEt) and amino acid amides was realized using o~-chymotrypsin (CT) in acetonitrile (MeCN) or acetonitrile/supercritical carbon dioxide (SCCO2) containing small amounts of water. In both solvent systems there was an optimum water content for peptide synthesis, above which peptide hydrolysis became more important. After an incubation for 5 hours, the yields of the peptide was 64 % in MeCN and 91% in MeCN/SCCO2, respectively.

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