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Enzymatic resolution of trans-2-hydroxycyclohexanecarbonitrile in supercritical carbon dioxide

✍ Scribed by Margita Utczás; Edit Székely; Enikő Forró; Áron Szőllősy; Ferenc Fülöp; Béla Simándi

Book ID
104099328
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
244 KB
Volume
52
Category
Article
ISSN
0040-4039

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✦ Synopsis

A novel, highly enantioselective (E ) 100) and environmentally benign method is presented for the kinetic resolution of trans-2-hydroxycyclohexanecarbonitrile in supercritical carbon dioxide. Using Candida antarctica Lipase B as a biocatalyst and vinyl acetate as an acyl donor, enantiomerically pure (1S,2R)-acetoxycyclohexanecarbonitrile and (1R,2S)-hydroxycyclohexanecarbonitrile were obtained in quantitative yields and excellent ee (98%) values.

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