Enzymatic synthesis of optically active 1- and 2-aminoalkanephosphonates

✍ Scribed by Chengye Yuan; Chengfu Xu; Yonghui Zhang

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 193 KB
• Volume: 59
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(03)00995-5

✦ Synopsis

A number of 1-and 2-aminoalkanephosphonates were resolved with high enantioselectivity by Candida antarctica lipase B-catalyzed acetylation. By this method, optically pure aminoalkanephosphonates and amidoalkanephosphonates, the precursors of the corresponding aminoalkanephosphonic acids, were synthesized.