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Enzymatic synthesis of [1-14C-N-acetyl, P18O2] cytidine monophosphate neuraminic acid

✍ Scribed by Erin E. Burke; Nicole A. Horenstein

Publisher: John Wiley and Sons
Year: 2004
Tongue: French
Weight: 152 KB
Volume: 47
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.889

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✦ Synopsis

A method for the enzymatic synthesis of [1-14 C-N-acetyl, P 18 O 2 ] cytidine monophosphate neuraminic acid (CMP-NeuAc) is described. Central to the synthesis of [1-14 C-N-acetyl, P 18 O 2 ]CMP-NeuAc was the enzymatic preparation of [g-P 18 O 3 ]ATP for use in a reaction with uridine kinase and cytidine to provide 5 0 -[P 18 O 3 ]CMP. The [1-14 C-N-acetyl, P 18 O 2 ]CMP-NeuAc isotopomer was then synthesized from a reaction involving nucleoside monophosphate kinase, pyruvate kinase and CMP-NeuAc synthetase. The isolated reaction yield was 35%.

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