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Enzymatic syntheses of GlcNAcβ1-2Man and Galβ1-4GlcNAcβ1-2Man as components of complex type sugar chains

✍ Scribed by Hiroshi Fujimoto; Megumi Isomura; Tatsuo Miyazaki; Ichiro Matsuo; Richard Walton; Tohru Sakakibara; Katsumi Ajisaka


Book ID
110372728
Publisher
Springer US
Year
1997
Tongue
English
Weight
400 KB
Volume
14
Category
Article
ISSN
1573-4986

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The first synthesis of neu5Acα2-3Galβ1-4
✍ Ichiro Matsuo; Megumi Isomura; Katsumi Ajisaka 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 212 KB

Glycopepfide (I), Neu5A~2-3Gall~l-4GlcNA~l-2Maactl-Ser, was synthesized using a chemoenzymatic strategy. Gal~l-4GlcNAcl~l\*2Man Ifisacd~ide was ~ using glycosidase assisted oligom:x:lutride synthesis. After coupling of this trisacchaxide with a sefine defivstive by chemical glycosylstion, sialic add