Several enzymatic alkoxycarbonylation processes are evaluated for the resolution of trans-N-benzyloxycarbonyl-4-(4%fluorophenyl)-3-hydroxymethylpiperidine, a chiral intermediate in the synthesis of (-)-paroxetine. Candida antarctica lipase B (CAL-B) catalyzes the enzymatic alkoxycarbonylation with d
✦ LIBER ✦
Enzymatic Resolution of trans -4-(4‘-Fluorophenyl)-3-hydroxymethylpiperidines, Key Intermediates in the Synthesis of (−)-Paroxetine
✍ Scribed by de Gonzalo, Gonzalo; Brieva, Rosario; Sánchez, Víctor M.; Bayod, Miguel; Gotor, Vicente
- Book ID
- 126219074
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 100 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3263
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