𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Enzymatic Resolution of trans -4-(4‘-Fluorophenyl)-3-hydroxymethylpiperidines, Key Intermediates in the Synthesis of (−)-Paroxetine

✍ Scribed by de Gonzalo, Gonzalo; Brieva, Rosario; Sánchez, Víctor M.; Bayod, Miguel; Gotor, Vicente


Book ID
126219074
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
100 KB
Volume
66
Category
Article
ISSN
0022-3263

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Enzymatic alkoxycarbonylation reactions
✍ Gonzalo de Gonzalo; Rosario Brieva; Vı́ctor M. Sánchez; Miguel Bayod; Vicente Go 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 201 KB

Several enzymatic alkoxycarbonylation processes are evaluated for the resolution of trans-N-benzyloxycarbonyl-4-(4%fluorophenyl)-3-hydroxymethylpiperidine, a chiral intermediate in the synthesis of (-)-paroxetine. Candida antarctica lipase B (CAL-B) catalyzes the enzymatic alkoxycarbonylation with d

Synthesis of punaglandin 4 by means of e
✍ Kenji Mori; Tadashi Takeuchi 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 814 KB

Abet?ZaCt --RmagkttXh 4, a chlorUtated tnarxne prosteno~d, we ~ynthi?~lPed EtWklng from two cbxal b.azldmg blocks. t+l-tartarrc acxd and (1~4R\_)-[-)-ri-t\_butyldlmethylss:yloxy-3-chloro-2-~l~te+l-o1, whxh we8 prepared by asymmetrx hydrolyss of the mnespmdmg (\*)-acetate rnth pg pancreatic lqmee. Pu