Optically active lactones were prepared by Horse Liver esterase catalyzed hydrolysis of bicyclic 'y-butyrolactones. Horse Liver esterase (HLE) IS less employed in organic synthesis than Porcine Liver esterase
Enzymatic resolution of racemic lactones
✍ Scribed by L. Blanco; E. Guibé-Jampel; G. Rousseau
- Book ID
- 104217520
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 231 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
Optically active 3-, 4-, 5-, or 6-methyl substituted seven-membered lactones were prepared by Candida antarctica lipase (CAL)-catalyzed kinetic resolution of the racemic lactones. Among these lactones, only in the case of 5-methylhexanolide (R)-isomer reacts faster than the other enantiomer, while t
## Abstract Preparation of chiral γ‐substituted‐γ‐lactones (**1**) through kinetic resolution is described. (__S__)‐(–)‐1‐Phenylethylamine (**2**) in the presence of anhydrous AlCl~3~ shows satisfactory levels of enantioselection in reaction with racemic γ‐substituted‐γ‐lactones **1,** where (__R__