While it is well documented that the overactivation of ionotropic glutamate receptors leads to seizures and excitotoxic injury, little is known about the role of metabotropic glutamate receptors (mGluRs) in epileptogenesis and neuronal injury. Intracerebroventricular (i.c.v.) infusion of the group I
Enzymatic resolution and pharmacological activity of the enantiomers of 3,5-dihydroxyphenylglycine, a metabotropic glutamate receptor agonist
โ Scribed by S. Richard Baker; John Goldsworthy; Raymond C. Harden; Craig R. Salhoff; Darryle D. Schoepp
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 289 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract 2โ(3,5โDichlorophenylcarbamoyl)cyclohexanecarboxylic acid (**1**) is a potent and selective positive allosteric modulator of metabotropic glutamate receptor subtypeโ 4 (mGluR4). The activity of **1** was reported to reside in the __cis__ diastereomer with equal potency between its enanti
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a โFull Textโ option. The original article is trackable v