In non-synchronized, subconfluent secondary cultures of rat cortical astrocytes, the selective group-I metabotropic glutamate (mGlu) receptor agonist 3,5dihydroxyphenylglycine (DHPG) increased [methyl-3 H]-thymidine incorporation. This effect was mediated by the activation of the mGlu5 receptor, whi
Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5
โ Scribed by Francesco Ferraguti; Corrado Corti; Enzo Valerio; Silvia Mion; John Xuereb
- Publisher
- Springer-Verlag
- Year
- 2001
- Tongue
- English
- Weight
- 578 KB
- Volume
- 137
- Category
- Article
- ISSN
- 0014-4819
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## Abstract The ฮณโaminobutyric acid (GABA) transporters GATโ1, GATโ2, GATโ3, and BGTโ1 have been cloned and identified according to their differential amino acid sequences and pharmacologic properties. In contrast to GATโ1, โ2, or โ3, BGTโ1 is capable of utilizing both GABA and betaine as substrate