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Enzymatic methods for the preparation of acetyl-CoA and analogs

โœ Scribed by Uta-Maria Billhardt; Philip Stein; George M. Whitesides


Book ID
103478520
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
712 KB
Volume
17
Category
Article
ISSN
0045-2068

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A new method for the preparation of 3-ketoacyl-CoA thioesters (from malonylsemialdehyde to long-chain and phenylpropanoic 3-keto derivatives) is described. It utilizes the facile, thermodynamically very favorable, hydration of 2-alkynoyl-CoA thioesters by enoyl-CoA hydratase. The method is simple an