𝔖 Bobbio Scriptorium
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Enzymatic formation of inosine 3′,5′-monophosphate and of 2′-deoxyguanosine 3′,5′-monophosphate: Inosinate and deoxyguanylate cyclase activity

✍ Scribed by David L. Garbers; Janice L. Suddath; Joel G. Hardman


Book ID
115734039
Publisher
Elsevier Science
Year
1975
Weight
752 KB
Volume
377
Category
Article
ISSN
0005-2744

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A series of novel small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH), based upon a 3-cyanoindole core, were explored. IMPDH catalyzes the rate determining step in guanine nucleotide biosynthesis and is a target for anticancer, immunosuppressive and antiviral therapy. The synthe