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Enzymatic formation and chemical synthesis of an active metabolite of 3β-hydroxy-5α-cholest-8(14)-en-15-one, a potent regulator of cholesterol metabolism

✍ Scribed by George J. Schroepfer Jr.; Hong-Seok Kim; Janice L. Vermilion; Thomas W. Stephens; Frederick D. Pinkerton; Dolores H. Needleman; William K. Wilson; Jan St. Pyrek

Book ID
115761282
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
487 KB
Volume
151
Category
Article
ISSN
0006-291X

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The X-ray crystal structure of 3~-benzoyloxy-6a-chloro-5a-cholest-7-ene (IV) was determined by the heavy atom method and ref'med to R ---0.063 (space group P2s, a --11.364, b = 11.089, c --12.232,/~ = 99.43 °, Z ---2). IV was previously shown to be an important intermediate in the acid-catalyzed iso