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Enzymatic basis for the non-linearity of hepatic elimination of propranolol in the isolated perfused rat liver

✍ Scribed by Ryozo Ishida; Kazuyoshi Suzuki; Yasuhiro Masubuchi; Shizuo Narimatsu; Shoichi Fujita; Tokuji Suzuki

Book ID
115783077
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
686 KB
Volume
44
Category
Article
ISSN
0006-2952

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The highly efficient hepatic extraction of propranolol by the isolated perfused rat liver does not diminish when albumin binding is increased from 30 to 75%. One possible explanation of this insensitivity of propranolol uptake to changes in albumin binding is the mediation of uptake of bound ligand