Enzymatic assays for 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline, a promising new “nonclassical” antifolate
✍ Scribed by J. J. Heusner; J. J. McCormack
- Book ID
- 102404517
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 277 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0022-3549
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A novel synthesis of the promising new herbicide 2- (2,6-dichloro-4pyridyl)-3-propargyl-5-ethyl-6-methyl-4(3H\_\_)-pyrimidinone ( 12) is reported which features (1) regioselective carbon, followed by nitrogen, dialkylation of an intermediate dianion, and (2) a tandem "one-pot" sequence of reactions
Synthesis of 2-(2,6-Dichloro-4-pyridyl)-3-propargyl-5-ethyl-6-methyl-4( 3H)-pyrimidinone, a Promising New Herbicide. -Condensation of the Michael acceptor (I) with the amidine (II) leads to formation of the dihydropyrimidone (III) which is readily converted to the title compound (IX) by a sequence