Environmentally friendly [Pd/Cu]-catalysed C3-alkenylation of free NH-indoles

✍ Scribed by Laurent Djakovitch; Pascal Rouge

• Book ID: 104010172
• Publisher: Elsevier Science
• Year: 2009
• Tongue: English
• Weight: 850 KB
• Volume: 140
• Category: Article
• ISSN: 0920-5861
• DOI: 10.1016/j.cattod.2008.07.013

✦ Synopsis

A new eco-efficient and environmentally friendly palladium/copper catalytic procedure for the C3alkenylation of free NH-indoles is reported. Using homogeneous or heterogeneous heterobimetallic [Pd/ Cu]-catalysts under mild reaction conditions (10 mol% Pd-catalyst and 10 mol% Cu-catalyst, 70 8C, air), substituted indoles are fully (58-82% isolated yields) and selectively (75-100% selectivity) converted to the expected 2-substituted-3-vinylindoles.