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Environmental Polymorphism Registry: Banking DNA to Discover the Source of Susceptibility

✍ Scribed by Angela Spivey

Book ID: 124322561
Publisher: Environmental Health Information Service
Year: 2006
Tongue: English
Weight: 840 KB
Volume: 114
Category: Article
ISSN: 0091-6765
DOI: 10.2307/3651753

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## Abstract Cigarette smoke can generate reactive oxygen species, which are capable of inducing double‐strand breaks (DSBs) in DNA. Polymorphisms in __XRCC2__ and __XRCC3__ genes, involved in DSBs repair pathways, may alter an individual's susceptibility to smoking‐related cancers. We investigated