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Enumeration of Listeria monocytogenes-reactive L3T4+ T cells activated during infection

✍ Scribed by Kaufmann, Stefan H.E.


Book ID
122387073
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
836 KB
Volume
1
Category
Article
ISSN
0882-4010

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Mice were infected with the intracellular bacterium, Lisferia monocytogenes, and T cell clones from spleens, lymph nodes and peritoneal exudates were established. The capacity of L3T4', Lyt2-T-cell clones to specifically lyse L. monocytogenes-infected macrophages was analyzed. As a source of target

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In mice Listeria monocytogenes infection induces a strong T cell response. In an attempt to quantitatively analyze the magnitude and kinetics of the CD4(+) and CD8(+) T cell response during L. monocytogenes infection in vivo we used a T cell transfer system that is independent of in vitro cell cultu