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Entropic Cost of Protein−Ligand Binding and Its Dependence on the Entropy in Solution

✍ Scribed by Irudayam, Sheeba Jem; Henchman, Richard H.


Book ID
125996889
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
560 KB
Volume
113
Category
Article
ISSN
0022-3654

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## Abstract It is an accepted practice in ligand design to introduce conformational constraint with the expectation of improving affinity, justified by the theoretical possibility that an unfavorable change in binding entropy will be reduced. This rationale of minimizing the entropic penalty throug