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Evaluation of protein-ligand binding free energy focused on its entropic components

โœ Scribed by Shuntaro Chiba; Yuich Harano; Roland Roth; Masahiro Kinoshita; Minoru Sakurai


Book ID
118284220
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
572 KB
Volume
33
Category
Article
ISSN
0192-8651

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## Abstract Noncovalent association of proteins to specific target sites on DNAโ€”a process central to gene expression and regulationโ€”has thus far proven to be idiosyncratic and elusive to generalizations on the nature of the driving forces. The spate of structural information on proteinโ€”DNA complexe