Photohalogenation of 3-Acetylcoumarins: Facile Synthesis of 3-(2-Amino-4-thiazolyl)coumarins and Their Conversion into 3-[2-(2,5-Dimethylpyrrol-1-yl)thiazol-4-yl]coumarins. -A facile synthesis of 3-(2-amino-4-thiazolyl)coumarins (III) by reacting acetylcoumarins (I) with thiourea under photohalogen
Ensembles of rings with a coumarin unit 1. Synthesis of 3-(2-R-thiazol-4-yl)-and 3-(4-R-thiazol-2-yl)coumarins
✍ Scribed by Ya. V. Belokon'; S. N. Kovalenko; A. V. Silin; V. M. Nikitchenko
- Publisher
- Springer US
- Year
- 1997
- Tongue
- English
- Weight
- 506 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0009-3122
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📜 SIMILAR VOLUMES
## Abstract magnified image A novel class of coumarin‐thiazole conjugated systems (1‐31) were synthesized by Hantzsch condensation between α‐bromo‐3‐acetyl coumarin and several thiosemicarbazone intermediates. This scaffold was also evaluated for selective antibacterial activity against 20 isolates
## Abstract 3‐Acetyl‐4‐hydroxy‐chromen‐2‐one (**1**) was brominated with phenyltrimethylammonium tribromide to afford 3‐(2‐bromoacetyl)‐4‐hydroxy‐chromen‐2‐one (**2**) whose reactions with thiourea, thioacetamide and ammonium dithiocarbamate gave respectively 3‐(2‐amino‐thiazol‐4‐yl)‐4‐hydroxy‐, 4‐
0 -(4-methyl-1,3-thiazol-5-yl)-2-oxo-2,3,2 0 0 0 ,3 0 0 0 ,5 0 0 0 ,6 0 0 0 ,7 0 0 0 ,7a 0 0 0 -octahydro-1Hindole-3-spiro-3'-1H-pyrrolizin-2 0 0 0 -yl]prop-2-en-1-one