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Synthesis and anti-Helicobacter pylori activity of 4-(coumarin-3-yl)thiazol-2-ylhydrazone derivatives

✍ Scribed by Franco Chimenti; Bruna Bizzarri; Adriana Bolasco; Daniela Secci; Paola Chimenti; Arianna Granese; Simone Carradori; Melissa D'Ascenzio; M. Maddalena Scaltrito; Francesca Sisto

Publisher: Journal of Heterocyclic Chemistry
Year: 2010
Tongue: English
Weight: 99 KB
Volume: 47
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.464

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✦ Synopsis

Abstract

magnified image A novel class of coumarin‐thiazole conjugated systems (1‐31) were synthesized by Hantzsch condensation between α‐bromo‐3‐acetyl coumarin and several thiosemicarbazone intermediates. This scaffold was also evaluated for selective antibacterial activity against 20 isolates of H. pylori clinical strains, including four metronidazole resistant ones. J. Heterocyclic Chem., (2010).

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