The enhancement of model hydrophilic (propranolol hydrochloride) and lipophilic (diazepam) drug penetration across rat and hairless mouse skin in vitro has been studied. Preliminary experiments established that most n-alkanes having chain lengths of between 7 and 16 promote the flux of both drugs. F
Enhancing effects of lipophilic vehicles on skin penetration of methyl nicotinate in vivo
β Scribed by Claudia S. Leopold; Bernhard C. Lippold
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 487 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
β¦ Synopsis
Vehicle effects may be caused by thermodynamic effects and by specific (penetration enhancing) effects. To investigate the effects
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