Sulphasalazine (SASP) is an immunomodulatory compound with disease-modifying activity in ulcerative colitis and in other autoimmune disorders. SASP was previously shown to prolong the survival of heart allografts in rats treated with cyclosporin A (CyA) for 9 days after transplantation. We have now
Enhancement of the immunosuppressive effect of cyclosporin A by ciprofloxacin in a rat cardiac allograft transplantation model
✍ Scribed by Kristian Riesbeck; Hanna Schatz; Öyivind Östraat; Gunnar Tufveson; Arne Forsgren; Henrik Ekberg
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 668 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0934-0874
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Recent studies suggested that conversion from cyclosporine A (CsA) to antimetabolic agents protects allograft vasculopathy. However, the mechanism of this beneficial effect by the conversion therapy is not fully understood. In the present study, we investigated the effects of conversion
## Background and Objective : Transplant vasculopathy is a leading cause of late cardiac graft loss. We have examined laserinduced fluorescence (LIF) spectroscopy as an optical diagnostic tool for detection of intimal plaque development and inflammatory cellular invasion in a rat model of aortic al
Anatomical and functional information (renography, perfusion) was obtained by MRI in a life-supporting transplantation model, in which Lewis rats received kidneys from Fisher 344 donors. Renography and perfusion analyses were carried out with Gd-DOTA and small particles of iron oxide (SPIO), respect
Recently, we reported that ciprofloxacin, an antimicrobial agent with ␥-aminobutyric acid (GABA A ) receptor antagonist properties, significantly increases hepatic regenerative activity in animal models of alcohol-induced liver disease and cirrhosis. In the present study, we documented the effects o