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Enhancement of renin activity by cyclosporine A

✍ Scribed by E. Müller-Schweinitzer; J. Mason; I. Olea Baza

Book ID
115886001
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
99 KB
Volume
183
Category
Article
ISSN
0014-2999

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Following the clinical observation of enhanced antineoplastic action of etoposide in the presence of cyclosporin A (CyA), we investigated this drug interaction in several in vitro and in vivo tumor systems. Macromolecular DNA damage induced by etoposide at drug levels comparable to plasma AUC values