𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Enhancement of phase-contrast MR angiography with superparamagnetic iron oxide

✍ Scribed by Akihiro Tanimoto; Yuji Yuasa; Kyoichi Hiramatsu

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
580 KB
Volume
8
Category
Article
ISSN
1053-1807

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The effect of superparamagnetic iron oxide particles (AMI‐227) was assessed in three‐dimensional (3D) phase‐contrast (PC) MR angiography (MRA), with various scanning parameters for rats at 1.5 T. The blood T1 and T2 before and after 20 μmol Fe/kg of AMI‐227 injection were measured sequentially at .47 T. The visualization of abdominal aorta, renal artery, inferior vena cava, and portal vein was respectively evaluated before and after AMI‐227 injection qualitatively by the four confidence levels and quantitatively by analysis of signal‐to‐noise ratio (SNR) of vessels. The blood T1 and T2 were sufficiently shortened for at least 1 hour after AMI‐227 injection. The visualization of each vessel was improved by AMI‐227 at various velocity encoding (VENC) value, suggesting the extended application of PC‐MRA in various conditions. The optimal flip angle was increased from 20° to 30° in higher VENC after AMI‐227 injection, resulting in higher signal from blood flow. Quantitative analyses showed that the optimal flip angle to achieve the maximum SNR seemed to be 20° in unenhanced images, but the optimal flip angle of the high speed flow was increased by contrast enhancement. The postcontrast PC‐MRA provides the increased sensitivity of slow flow components, even with a high VENC gradient. AMI‐227 can significantly improve SNR to blood vessels during 3D‐PC‐MRA with various scanning parameters.

📜 SIMILAR VOLUMES

Evaluation of portal MR angiography usin
Evaluation of portal MR angiography using superparamagnetic iron oxide
✍ F. D. Knollmann; J. C. Böck; S. Teltenkötter; W. Wlodarczyk; A. Mühler; Th. J. V 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 880 KB

## Abstract The purpose of our research was to determine the effects of superparamagnetic iron oxide on MR imaging of the portal venous system. Eight piglets were examined in deep anaesthesia and respiratory arrest using a time‐of‐flight magnetic resonance fast low angle shot, two‐dimensional angio

Contrast enhancement with GD-EOB-DTPA in
Contrast enhancement with GD-EOB-DTPA in MR imaging of hepatocellular carcinoma in mice: A comparison with superparamagnetic iron oxide
✍ Makoto Fujita; Reiko Yamamoto; Bernhard Fritz-Zieroth; Tsuyoshi Yamanaka; Masaya 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 797 KB

## Abstract The purpose of this study was to evaluate the ability of the new liver‐specific magnetic resonance contrast agent gadolinium‐ethoxybenzyl‐diethylenetriamine penta‐acetic acid (Gd‐EOB‐DTPA) to detect hepatocellular carcinoma (HCC). Seventeen mice with 66 chemically induced HCCs underwent

Feasibility of concurrent dual contrast
Feasibility of concurrent dual contrast enhancement using CEST contrast agents and superparamagnetic iron oxide particles
✍ Assaf A. Gilad; Hanneke W.M. van Laarhoven; Michael T. McMahon; Piotr Walczak; A 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 643 KB

## Abstract A major challenge for cellular and molecular MRI is to study interactions between two different cell populations or biological processes. We studied the possibility to simultaneously image contrast agents based on two different MRI contrast mechanisms: chemical exchange saturation trans

Contrast-enhanced MR imaging of liver an
Contrast-enhanced MR imaging of liver and spleen: First experience in humans with a new superparamagnetic iron oxide
✍ Bernd Hamm; Thomas Staks; Matthias Taupitz; Renate Maibauer; Andrea Speidel; Ale 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English

## Abstract The aim of this prospective study was to obtain the first human safety and magnetic resonance (MR) imaging results with a new formulation of superparamagnetic iron oxide (SPIO) (SHU 555 A). The SPIO was tested at four iron doses, from 5 to 40 μmol/kg. Laboratory tests and clinical measu

Applications of ultrasmall superparamagn
Applications of ultrasmall superparamagnetic iron oxide contrast agents in the MR study of animal models
✍ Ed X. Wu; Haiying Tang; Jens H. Jensen 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 324 KB

## Abstract Ultrasmall superparamagnetic iron oxide nanoparticles have been widely used during the past decade as MR intravascular contrast agents in the study of animal models. Such agents enhance both __T__~1~ and __T__~2~/__T__~2~\* relaxation, although for animal studies it is the later type of

Diagnosis of colorectal hepatic metastas
Diagnosis of colorectal hepatic metastases: Comparison of contrast-enhanced CT, contrast-enhanced US, superparamagnetic iron oxide-enhanced MRI, and gadoxetic acid-enhanced MRI
✍ Ali Muhi; Tomoaki Ichikawa; Utaroh Motosugi; Hironobu Sou; Hiroto Nakajima; Kats 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 513 KB

## Abstract ## Purpose: To compare the diagnostic accuracy of contrast‐enhanced computed tomography (CE‐CT), contrast‐enhanced ultrasonography (CE‐US), superparamagnetic iron oxide‐enhanced magnetic resonance imaging (SPIO‐MRI), and gadoxetic acid‐enhanced MRI (Gd‐EOB‐MRI) in the evaluation of col