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Enhancement of methotrexate cytotoxicity towards the MDA.MB.436 human breast cancer cell line by dipyridamole: The role of methotrexate polyglutamates

✍ Scribed by D.G. Kennedy; H.W. Van den Berg; R. Clarke; R.F. Murphy

Book ID: 115779018
Publisher: Elsevier Science
Year: 1986
Tongue: English
Weight: 487 KB
Volume: 35
Category: Article
ISSN: 0006-2952
DOI: 10.1016/0006-2952(86)90385-0

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## Methods Mitoxantrone was purchased from Lederle (France) and doxorubicin from Dakota (France). Stock solutions stored at Ϫ20°C (9 ϫ 10 Ϫ4 M for doxorubicin and 4 ϫ 10 Ϫ3 M for mitoxantrone) and dilutions of doxorubicin and mitoxantrone were freshly prepared in physiological saline solution, NaC