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Enhancement of doxorubicin cytotoxicity by polyunsaturated fatty acids in the human breast tumor cell line MBA-MB-231: Relationship to lipid peroxidation

✍ Scribed by Emmanuelle Germain; Véronique Chajès; Sophie Cognault; Claude Lhuillery; Philippe Bougnoux


Publisher
John Wiley and Sons
Year
1998
Tongue
French
Weight
99 KB
Volume
75
Category
Article
ISSN
0020-7136

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✦ Synopsis


Methods

Mitoxantrone was purchased from Lederle (France) and doxorubicin from Dakota (France). Stock solutions stored at Ϫ20°C (9 ϫ 10 Ϫ4 M for doxorubicin and 4 ϫ 10 Ϫ3 M for mitoxantrone) and dilutions of doxorubicin and mitoxantrone were freshly prepared in physiological saline solution, NaCl 0.9%.

DHA (22:6n-3), eicosapentaenoic acid (20:5n-3), arachidonic acid (20:4n-6), ␥-linolenic acid (18:3n-6), ␣-linolenic acid (18: