Enhancement of interleukin-2 release in rats by treatment with bleomycin and Adriamycin in vivo

✍ Scribed by Tarek A. Abdul Hamied; John L. Turk

• Book ID: 104660413
• Publisher: Springer-Verlag
• Year: 1987
• Tongue: English
• Weight: 495 KB
• Volume: 25
• Category: Article
• ISSN: 0340-7004
• DOI: 10.1007/bf00199154

✦ Synopsis

Spleen ceils from rats previously injected with bleomycin (10 mg/kg) or Adriamycin (1 mg/kg) were able to release higher levels of interleukin-2 (IL-2) than cells from untreated animals. The difference in IL-2 release was detected after the cells were exposed to a suboptimal dose of concanavalin A (0.5 ~tg/ml) for 24 h. By cytofluorimetry, these drugs did not change the proportion of W3/25 + (helper) or OX-8 + (suppressor) T-cell subsets. In contrast, the immunosuppressive drug cyclophosphamide inhibited the IL-2 release from spleen cells under the same conditions. It is suggested that some anti-cancer antibiotics may be able to enhance the release of IL-2 while other cytotoxic drugs with more immunosuppressive potential could inhibit the release of this mediator.