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Enhancement of IgG production elicited in mice by treatment with anti-CD8 antibody

✍ Scribed by Jean-Paul Coutelier

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
403 KB
Volume
21
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

Injection of an anti‐CD8 monoclonal antibody into mice was followed by an increase in the production of immunoglobulins of the IgG~1~, IgG~2a~, and IgG~2b~, but neither the IgG~3~ nor the IgM isotypes. A maximal effect was observed 6 days after administration of 10μg antibody. However, no modification of spleen cell proliferation was elicited by the anti‐CD8 treatment. Virally induced IgG~2a~ and IgG~2b~ secretion remained unchanged in mice infected with lactate dehydrogen‐ase‐elevating virus that received a concomitant injection of anti‐CD8 antibody, whereas an enhancement of IgG~1~ was observed. Simultaneous treatment with an anti‐CD4 antibody abrogated the immunoglobulin secretion triggered by anti‐CD8. These results suggest that immunoglobulin production in unmanipulated mice is controlled by CD8^+^ lymphocytes.

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