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Enhancement of HIV-1 Infectivity by Simple, Self-Assembling Modular Peptides

✍ Scribed by Easterhoff, David; DiMaio, John T.M.; Doran, Todd M.; Dewhurst, Stephen; Nilsson, Bradley L.


Book ID
119208774
Publisher
Biophysical Society
Year
2011
Tongue
English
Weight
992 KB
Volume
100
Category
Article
ISSN
0006-3495

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We have previously demonstrated that a 23-amino acid peptide derived from the V3 loop of the surface glycoprotein of the HIV-1 strain MN is able to bind CD4 and to enhance HIV-1 infection. Further studies have suggested that the peptide/CD4 interaction induces an increase in both CD4 expression and