Enhancement of fluorinated pyrimidine-in
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Chun-Ming Tsai; Adi F. Gazdar; Carmen Allegra; Reury-Perng Perng; Barnett S. Kra
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Article
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1990
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John Wiley and Sons
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French
β 535 KB
Reduced folates have been shown to increase the cytotoxicity of 5-fluorouracil (FUra) by stabilizing the fluorodeoxyuridine monophosphate:thymidylate synthase complex, thus increasing the block in the DNA synthetic pathway. Using an in vitro tetrazolium colorimetric ( M T Q cytotoxic assay, we teste