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Enhancement of fibrin binding and activation of plasminogen by staplabin through induction of a conformational change in plasminogen

✍ Scribed by Ritsuko Takayasu; Keiji Hasumi; Chikara Shinohara; Akira Endo


Book ID
117108416
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
539 KB
Volume
418
Category
Article
ISSN
0014-5793

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit