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Enhancement of cytokine-mediated NF-κB activation by phosphatidylinositol 3-kinase inhibitors in monocytic cells

✍ Scribed by Eun-Kyoung Choi; Ho-Cheol Jang; Jae-Hyung Kim; Hyun-Jin Kim; Ho-Cheol Kang; Yun-Woong Paek; Hyun-Chul Lee; Seung-Hoon Lee; Won-Mann Oh; In-Chol Kang

Book ID: 116575939
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 196 KB
Volume: 6
Category: Article
ISSN: 1567-5769
DOI: 10.1016/j.intimp.2006.01.007

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## Background Phosphatidylinositol (PI) 3-kinase is activated by a variety of growth factor receptors and the PI 3-kinase/Akt signaling pathway is a key regulator of cell proliferation and survival. The downstream targets of PI 3-kinase/Akt signaling include direct regulators of cell cycle progress