Enhancement of catalytic activity of porcine pancreatic lipase by reductive alkylation
β Scribed by T. N. B. Kaimal; M. Saroja
- Publisher
- Springer Netherlands
- Year
- 1989
- Tongue
- English
- Weight
- 350 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0141-5492
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Cyclic carbonates, 1,3-dioxolan-2-ones were enantioselectlvely hydrolyzed by porcine pancreatic lipase to give optically active 1,2alkanediols. ## 1989). Recently, authors have been revealed usefullness of resolution of alcohols through the carbonates by lipase-catalyzed enantioselective hydrolys
## Abstract The resolution of 2βamino alcohols (II), protected by urethaneβtype groups, either via porcine pancreatic lipase (PPL) hydrolysis of the corresponding racemic acetates (I) or via PPLβcatalyzed transesterification of racemic alcohols (II) is studied.
Crude preparations of porcine pancreatic lipase (PPL) contain apart from the PPL a significant number of other hydrolases as impurities. The treatment of crude PPL preparations with humid supercritical carbon dioxide leads to a quality improvement of the preparations. Five hundred milligrams of PPL