𝔖 Bobbio Scriptorium
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Enhancement of carcinoembryonic antigen expression by interferon

✍ Scribed by Abdelfattah M. Attallah; Charles F. Needy; Philip D. Noguchi; Bennett L. Elisberg

Book ID
102276566
Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
340 KB
Volume
24
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Human interferon decreased DNA but not RNA synthesis in a human colon carcinoma cell line, WiDr; in addition, there was a two‐ to three‐fold increase in the expression of a tumor‐associated antigen, carcinoembryonic antigen. In contrast, interferon had no effect on a normal human diploid cell line, WI‐38. Thus, in addition to its anti‐cellular effect against tumor cells, interferon can also modulate tumor antigenicity.

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Using a panel of monoclonal and polyclonal antibodies raised against human carcinoembryonic antigen (CEA) and CEA-related molecules, we detected strong expression of an antigen, with immunoreactivity consistent with non-specific cross-reacting antigen (NCA) (CD66c), in all of 26 normal human nail sp