Enhanced repair of DNA interstrand crosslinks in S phase
β Scribed by Veronika Mladenova; George Russev
- Book ID
- 116466438
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 241 KB
- Volume
- 580
- Category
- Article
- ISSN
- 0014-5793
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract DNA damage by agents crosslinking the strands presents a formidable challenge to the cell to repair for survival and to repair accurately for maintenance of genetic information. It appears that repair of DNA crosslinks occurs in a path involving double strand breaks (DSBs) in the DNA. M
## Abstract DNA interstrand crosslinks (ICLs) are induced by a number of bifunctional antitumor drugs such as cisplatin, mitomycin C, or the nitrogen mustards as well as endogenous agents formed by lipid peroxidation. The repair of ICLs requires the coordinated interplay of a number of genome maint