Programmed cell death 1 (PD-1) and its l
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Liqing Wang; Rongxiang Han; Wayne W. Hancock
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Article
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2007
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John Wiley and Sons
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English
⚖ 429 KB
## Abstract Programmed cell death‐1 (PD‐1, CD279) and its widely expressed, inducible ligand, PD‐L1 (CD274), together dampen T cell activation, but whether they are essential for allograft tolerance is unknown. We show, using gene‐deficient mice and blocking mAbs in wild‐type mice, that costimulati