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Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain

✍ Scribed by Parada, Camilo A.; Roeder, Robert G.


Book ID
109798500
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
947 KB
Volume
384
Category
Article
ISSN
0028-0836

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Cdc2 kinase triggers the entry of mammalian cells into mitosis, the only cell cycle phase in which transcription is globally repressed. We show here that Cdc2 kinase phosphorylates components of the RNA polymerase II transcription machinery including the RNA polymerase II carboxy-terminal repeat dom