Enhanced neutral protease activity in proliferating rheumatoid synovial cells
โ Scribed by Victor B. Hatcher; Joanne P. Borg; Mindy Levitt; Carol Smith
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 773 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective To investigate whether proteaseโactivated receptor 1 (PARโ1) and/or PARโ2 promotes the invasiveness/proliferation of synovial fibroblasts (SFs) and to determine the signaling mechanisms of these pathways. ## Methods SFs were isolated from the synovial tissue of patients
## Abstract Given the importance of interleukinโ1 in both rheumatic diseases and the modulation of cell metabolic activities, we studied the action of this cytokine on the neutral amino acid transport A system on rheumatoid synovial cells. In these cells ILโ1 (1ng/ml) induced amino transport stimul