Enhanced in vivo lipid peroxidation in scleroderma spectrum disorders
✍ Scribed by Jean-Luc Cracowski; Claudine Marpeau; Patrick H. Carpentier; Bernard Imbert; Mark Hunt; Françoise Stanke-Labesque; Germain Bessard
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 86 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0004-3591
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## Abstract The prevalence of scleroderma‐type capillary abnormalities, as observed by in vivo microscopy, was determined in 173 patients from three rheumatic disease centers. The patients had a variety of connective tissue diseases: scleroderma (systemic sclerosis) 50; systemic lupus erythematosus
Thiobarbituric acid (TBA) assays which have been modified for detection of lipid hydroperoxides appear to be useful for demonstration of in vivo lipid peroxidation. Since these methods require heating tissue membranes with the buffered TBA, there is a possibility of interference from the detection o