The pathogenesis of alcohol-induced liver disease involves the adverse effects of ethanol metabolites and oxidative tissue injury. Previous studies indicated that covalent protein adducts with reactive aldehydes may be formed in alcohol consumers. To study the role of such protein adducts in the dev
End products of lipid peroxidation in alcohol-induced liver disorders
β Scribed by A. S. Loginov; K. D. Dzhalalov; A. N. Erin; L. L. Prilipko
- Publisher
- Springer US
- Year
- 1986
- Tongue
- English
- Weight
- 329 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0007-4888
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from their site of origin to attack distant targets and form Lipid peroxidation is an autocatalytic mechanism leading to covalent links with various molecules (adducts). 2 Different oxidative destruction of cellular membranes. The deleterious cytotoxic effects of MDA and HNE adduct formation have co
The precise role of lipid peroxidation in the pathogenesis of alcoholic liver disease is still being debated. To explore the issue, this study was undertaken to investigate the status of lipid peroxidation, antioxidants and prooxidants at two discrete stages of experimental alcoholic liver disease.