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Enhanced Immunogenicity of HPV 16 E7 Fusion Proteins in DNA Vaccination

✍ Scribed by Nico Michel; Wolfram Osen; Lutz Gissmann; Ton N.M Schumacher; Hanswalter Zentgraf; Martin Müller

Book ID
112273934
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
328 KB
Volume
294
Category
Article
ISSN
0042-6822

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Enhancement of immunogenicity of HPV16 E7 oncogene by fusion with E. coli β-glucuronidase
✍ Michal Šmahel; Dana Pokorná; Jana Macková; Josef Vlasák 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 395 KB

## Abstract ## Background Human papillomavirus type 16 (HPV16) E7 is an unstable oncoprotein with low immunogenicity. In previous work, we prepared the E7GGG gene containing point mutations resulting in substitution of three amino acids in the pRb‐binding site of the HPV16 E7 protein. ## Methods