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Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints

✍ Scribed by Fionula M. Brennan; Deena L. Gibbons; Andrew P. Cope; Marc Feldmann; Tracey Mitchell; Ravinder N. Maini


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
694 KB
Volume
22
Category
Article
ISSN
0014-2980

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## Abstract ## Objective To investigate the roles of MAPKs and NF‐κB in tumor necrosis factor α (TNFα)–induced expression of vascular cell adhesion molecule 1 (VCAM‐1) in human rheumatoid arthritis synovial fibroblasts (RASFs). ## Methods Human RASFs were isolated from synovial tissue obtained f