Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

✍ Scribed by Monteiro, Diana C. F.; Phillips, Roger M.; Crossley, Benjamin D.; Fielden, Jake; Willans, Charlotte E.

• Book ID: 119941573
• Publisher: Royal Society of Chemistry
• Year: 2012
• Tongue: English
• Weight: 185 KB
• Volume: 41
• Category: Article
• ISSN: 1477-9226
• DOI: 10.1039/C2DT12399A

✦ Synopsis

A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.