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Chiral bidentate N -heterocyclic carbene complexes of Rh and Pd

✍ Scribed by Ren, Li; Chen, Austin C; Decken, Andreas; Crudden, Cathleen M

Book ID
120399423
Publisher
NRC Research Press
Year
2004
Tongue
French
Weight
354 KB
Volume
82
Category
Article
ISSN
0008-4042

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A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.