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Enhanced ceramide-induced apoptosis in ceramide kinase overexpressing cells

✍ Scribed by Christine Graf; Philipp Rovina; Loïc Tauzin; Andrea Schanzer; Frédéric Bornancin

Book ID
116294258
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
212 KB
Volume
354
Category
Article
ISSN
0006-291X

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Ceramide is a sphingolipid that has been implicated both in apoptosis and protection from cell death. We show that in both rat cerebellar granule cells and cortical neuronal cultures application of C(2)-ceramide causes cell death in a dose- and time-dependent manner. Similar effects were observed wi