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Enhanced bioavailability of nano-sized chitosan–atorvastatin conjugate after oral administration to rats

✍ Scribed by Mohammed Anwar; Musarrat H. Warsi; Neha Mallick; Sohail Akhter; Sachin Gahoi; Gaurav K. Jain; Sushma Talegaonkar; Farhan J. Ahmad; Roop K. Khar

Book ID
113592496
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
969 KB
Volume
44
Category
Article
ISSN
0928-0987

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## Abstract Paclitaxel is a substrate of the efflux transporters such as P‐glycoprotein, and is mainly metabolized by the liver. Schisandrol B (Sch B), one of the active components in Schisandra, has been reported to be able to inhibit the activity of P‐gp and CYP3A. It might be possible that Sch B