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Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin

✍ Scribed by Jun-Shik Choi; Byung-Wok Jo; Youn-Chul Kim


Book ID
116437199
Publisher
Elsevier Science
Year
2004
Tongue
French
Weight
181 KB
Volume
57
Category
Article
ISSN
0939-6411

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## Abstract Paclitaxel is a substrate of the efflux transporters such as P‐glycoprotein, and is mainly metabolized by the liver. Schisandrol B (Sch B), one of the active components in Schisandra, has been reported to be able to inhibit the activity of P‐gp and CYP3A. It might be possible that Sch B