Enhancement of oral bioavailability of p
Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats
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Jing Jin; Huichang Bi; Jinqing Hu; Guoping Zhong; Lizi Zhao; Zhiying Huang; Min
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Article
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2010
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John Wiley and Sons
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English
β 90 KB
π 2 views
## Abstract Paclitaxel is a substrate of the efflux transporters such as Pβglycoprotein, and is mainly metabolized by the liver. Schisandrol B (Sch B), one of the active components in Schisandra, has been reported to be able to inhibit the activity of Pβgp and CYP3A. It might be possible that Sch B