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Engrailed-2 negatively regulates the onset of perinatal Purkinje cell differentiation

✍ Scribed by Jakob Jankowski; Martin I. Holst; Christian Liebig; John Oberdick; Stephan L. Baader

Book ID: 102808888
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 791 KB
Volume: 472
Category: Article
ISSN: 0021-9967
DOI: 10.1002/cne.20059

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Purkinje cell degeneration (pcd) is an autosomal recessive mutation in the mouse characterized by an almost complete loss of cerebellar Purkinje neurons between postnatal days 22 and 28. The pcd gene has not been identified, however, a relationship between activation of specific genes and cell death