Engineering of vesicle trafficking improves heterologous protein secretion in Saccharomyces cerevisiae
โ Scribed by Jin Hou; Keith Tyo; Zihe Liu; Dina Petranovic; Jens Nielsen
- Book ID
- 113964226
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 586 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1096-7176
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Glutathione is excreted in a dose-dependent, non-stoichiometric fashion from Saccharomyces cerevisiae cells expressing and secreting Bovine Pancreatic Trypsin Inhibitor (BPTI), a small, disulfide-bonded protein. Glutathione excretion commences 40 hours following induction of BPTI synthesis. Expressi
The yeast Saccharomyces cerevisiae is a widely used cell factory for the production of fuels and chemicals, and it is also provides a platform for the production of many heterologous proteins of medical or industrial interest. Therefore, many studies have focused on metabolic engineering S. cerevisi